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Human NEFL Protein
Cat.#：TD-P-1009
Size： 50ug
Protein Name： NEFL
Synonym： NFL; NF-L; NF68; CMT1F; CMT2E
Uniprot No.： P07196
Expression System： E. Coli
Compound Identity： NEFL(e3)-his
Full Length or Truncated：Truncated
Molecular Weight： 32kD
Form： freeze-dried powder
Storage： -80°C (as supplied)
Stability： ≤6 months
Purity： ≥85% estimated by SDS-PAGE
Supplied in： 1×PBS (pH 7.2)
Background
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
SDS-PAGE Validation
12 % SDS-PAGE 1 2 | Lane Description Lane 1： Protein Marker Lane 2： NEFL(e3)-pET21(1：5 dilution) |
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