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CD3 epsilon Rabbit mAb

Cat.#：R23808
Size：20ul  50ul 100ul

Background

Swiss-Prot Acc.P07766.Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).

Alternative NamesT3E; TCRE; IMD18

ImmunogenA synthetic peptide of human CD3 epsilon

Cellular localizationCell membrane, Membrane

Buffer System50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Dilution RatioWB: 1/1000-1/5000 IHC: 1/50-1/200 IP: 1/20

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma,

-delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex.
This complex plays an important role in coupling antigen recognition to

Gene Description

several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the
same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause
immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]